
Combine the buttermilk, garlic powder, onion powder, salt, and pepper in a resealable plastic bag. Add the chicken pieces, seal, shake the bag to stir and coat the chicken well. Refrigerate for at least 4 hours or overnight, flipping the bag a few times.
Mix together the flour, garlic powder, onion powder, paprika, salt, and pepper in a shallow dish. Remove half of the chicken from the brine and let the excess brine drip off.
Dredge the chicken in the flour mixture and place on a baking sheet.
Preheat the air fryer to 400°F. Spray the air fryer basket and chicken pieces with cooking spray.
Place the chicken in the basket, skin side down, and spray again.
Cook for 20 minutes, flipping after 10 minutes, until the internal temperature reaches 165°F in the thicket part of each piece. Remove the chicken from air fryer and place on a wire rack.
Repeat with the remaining chicken and dredge. Serve immediately.