
Preheat oven to 350°F. Spray a loaf pan with nonstick cooking spray.
In a medium bowl, whisk together the flour, pumpkin pie spice, baking soda, and salt. Set aside.
In a stand mixer with a whisk attachment or in a large bowl with a hand mixer, mix the butter, cane sugar, and light brown sugar until light and fluffy, 2 minutes. Add the eggs, one at a time, until incorporated. Add the canned pumpkin and vanilla extract and mix to combine.
Add the dry ingredients and mix until no streaks of flour remain. Pour the batter into the prepared loaf pan and sprinkle with the pumpkin seeds, if using.
Bake 50-55 minutes until a toothpick inserted in the center of the loaf comes out clean. Remove from the oven and let the bread cool completely in the pan set on a wire rack before slicing.